Contribution of Immunological Memory to Protective Immunity Conferred by a Bacillus anthracis Protective Antigen-Based Vaccine
نویسندگان
چکیده
منابع مشابه
Contribution of immunological memory to protective immunity conferred by a Bacillus anthracis protective antigen-based vaccine.
Protective antigen (PA)-based vaccination is an effective countermeasure to anthrax infection. While neutralizing anti-PA antibody titers elicited by this vaccine serve as good correlates for protection against anthrax (S. Reuveny, M. D. White, Y. Y. Adar, Y. Kafri, Z. Altboum, Y. Gozes, D. Kobiler, A. Shafferman, and B. Velan, Infect. Immun. 69:2888-2893, 2001), no data are available on the co...
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Correlates between immunological parameters and protection against Bacillus anthracis infection in animals vaccinated with protective antigen (PA)-based vaccines could provide surrogate markers to evaluate the putative protective efficiency of immunization in humans. In previous studies we demonstrated that neutralizing antibody levels serve as correlates for protection in guinea pigs (S. Reuve...
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Background: DNA immunization with plasmid DNA encoding bacterial, viral, parasitic and tumor antigens has been reported to trigger protective immunity. Objective: To evaluate the use of a DNA immunization strategy for protection against anthrax, a plasmid was constructed. Methods: The partialsequence of protective antigen of Bacillus anthracis, amino acids 175-764, as a potent immunogenic targe...
متن کاملconstruction of a eukaryotic plasmid encoding bacillus anthracis protective antigen, a candidate for dna vaccine
background: dna immunization with plasmid dna encoding bacterial, viral, parasitic and tumor antigens has been reported to trigger protective immunity. objective: to evaluate the use of a dna immunization strategy for protection against anthrax, a plasmid was constructed. methods: the partialsequence of protective antigen of bacillus anthracis, amino acids 175-764, as a potent immunogenic targe...
متن کاملOral administration of a Salmonella enterica-based vaccine expressing Bacillus anthracis protective antigen confers protection against aerosolized B. anthracis.
Bacillus anthracis is the causative agent of anthrax, a disease that affects wildlife, livestock, and humans. Protection against anthrax is primarily afforded by immunity to the B. anthracis protective antigen (PA), particularly PA domains 4 and 1. To further the development of an orally delivered human vaccine for mass vaccination against anthrax, we produced Salmonella enterica serovar Typhim...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2004
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.72.6.3471-3477.2004